| Sanford Hospital Webster - CAH | Webster, SD | Critical Access Hospitals | Voluntary non-profit - Private | Not rated |
| Sanford Medical Center Aberdeen | Aberdeen, SD | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Sanford Usd Medical Center | Sioux Falls, SD | Acute Care Hospitals | Voluntary non-profit - Private | 5 stars |
| Sanford Vermillion Medical Center | Vermillion, SD | Critical Access Hospitals | Voluntary non-profit - Private | Not rated |
| Sioux Falls Specialty Hospital | Sioux Falls, SD | Acute Care Hospitals | Proprietary | Not rated |
| Sioux Falls VA Medical Center | Sioux Falls, SD | Acute Care - Veterans Administration | Veterans Health Administration | 5 stars |
| South Dakota Human Services Center | Yankton, SD | Psychiatric | Government - State | Not rated |
| St Michael's Hospital - CAH | Tyndall, SD | Critical Access Hospitals | Government - Local | Not rated |
| VA Black Hills Healthcare System | Fort Meade, SD | Acute Care - Veterans Administration | Veterans Health Administration | 5 stars |
| Wagner Community Memorial Hospital - CAH | Wagner, SD | Critical Access Hospitals | Voluntary non-profit - Private | Not rated |
| Winner Regional Healthcare Center - CAH | Winner, SD | Critical Access Hospitals | Voluntary non-profit - Private | Not rated |