| Prisma Health Oconee Memorial Hospital | Seneca, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Richland Hospital | Columbia, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| Prisma Health Tuomey Hospital | Sumter, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| Rebound Behavioral Health | Lancaster, SC | Psychiatric | Proprietary | Not rated |
| Roper Hospital | Charleston, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Roper St Francis Hospital-Berkeley Inc | Summerville, SC | Acute Care Hospitals | Voluntary non-profit - Private | 5 stars |
| Self Regional Healthcare | Greenwood, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Shriners Hospitals for Children | Greenville, SC | Childrens | Voluntary non-profit - Private | Not rated |
| Spartanburg Medical Center | Spartanburg, SC | Acute Care Hospitals | Government - Hospital District or Authority | 2 stars |
| Springbrook Behavioral Health System | Travelers Rest, SC | Psychiatric | Proprietary | Not rated |
| St Francis-Downtown | Greenville, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Three Rivers Behavioral Health | West Columbia, SC | Psychiatric | Proprietary | Not rated |
| Tidelands Georgetown Memorial Hospital | Georgetown, SC | Acute Care Hospitals | Voluntary non-profit - Private | 2 stars |
| Tidelands Waccamaw Community Hospital | Murrells Inlet, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Trident Medical Center | Charleston, SC | Acute Care Hospitals | Proprietary | 3 stars |
| Union Medical Center | Union, SC | Acute Care Hospitals | Voluntary non-profit - Other | Not rated |