| Abbeville Area Medical Center | Abbeville, SC | Critical Access Hospitals | Voluntary non-profit - Other | Not rated |
| Aiken Regional Medical Center | Aiken, SC | Acute Care Hospitals | Proprietary | 2 stars |
| Allendale County Hospital | Fairfax, SC | Critical Access Hospitals | Government - Local | Not rated |
| Anmed Health | Anderson, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Beaufort County Memorial Hospital | Beaufort, SC | Acute Care Hospitals | Government - Local | 4 stars |
| Bon Secours-St Francis Xavier Hospital | Charleston, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| Cannon Memorial Hospital | Pickens, SC | Acute Care Hospitals | Voluntary non-profit - Private | Not rated |
| Carolina Ctr for Behavioral Health,the | Greer, SC | Psychiatric | Proprietary | Not rated |
| Carolina Pines Regional Medical Center | Hartsville, SC | Acute Care Hospitals | Proprietary | 2 stars |
| Charleston VA Medical Center | Charleston, SC | Acute Care - Veterans Administration | Veterans Health Administration | 5 stars |
| Cherokee Medical Center | Gaffney, SC | Acute Care Hospitals | Government - Hospital District or Authority | 2 stars |
| Coastal Carolina Hospital | Hardeeville, SC | Acute Care Hospitals | Proprietary | 4 stars |
| Colleton Medical Center | Walterboro, SC | Acute Care Hospitals | Proprietary | 3 stars |
| Columbia Sc VA Medical Center | Columbia, SC | Acute Care - Veterans Administration | Veterans Health Administration | 5 stars |
| Conway Medical Center | Conway, SC | Acute Care Hospitals | Voluntary non-profit - Private | 2 stars |
| Edgefield County Healthcare an Affiliate of Self R | Edgefield, SC | Critical Access Hospitals | Voluntary non-profit - Private | Not rated |
| G Werber Bryan Psych Hosp | Columbia, SC | Psychiatric | Government - State | Not rated |
| Grand Strand Regional Medical Center | Myrtle Beach, SC | Acute Care Hospitals | Proprietary | 2 stars |
| Hampton Regional Medical Center | Varnville, SC | Acute Care Hospitals | Voluntary non-profit - Private | Not rated |
| Kershawhealth | Camden, SC | Acute Care Hospitals | Proprietary | 3 stars |
| Lexington Medical Center | West Columbia, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| Lighthouse Behavioral Health Hospital | Conway, SC | Psychiatric | Proprietary | Not rated |
| McLeod Health Cheraw | Cheraw, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| McLeod Health Clarendon | Manning, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| McLeod Loris Hospital | Loris, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| McLeod Medical Center - Dillon | Dillon, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| McLeod Regional Medical Center-Pee Dee | Florence, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| Mount Pleasant Hospital | Mount Pleasant, SC | Acute Care Hospitals | Voluntary non-profit - Private | 5 stars |
| MUSC Health Chester Medical Center | Chester, SC | Acute Care Hospitals | Proprietary | Not rated |
| MUSC Health Columbia Medical Center Downtown | Columbia, SC | Acute Care Hospitals | Voluntary non-profit - Private | 3 stars |
| MUSC Health Florence Medical Center | Florence, SC | Acute Care Hospitals | Government - State | 3 stars |
| MUSC Health Lancaster Medical Center | Lancaster, SC | Acute Care Hospitals | Proprietary | 4 stars |
| MUSC Health Marion Medical Center | Mullins, SC | Acute Care Hospitals | Government - State | 3 stars |
| MUSC Medical Center | Charleston, SC | Acute Care Hospitals | Government - Hospital District or Authority | 2 stars |
| Newberry County Memorial Hospital | Newberry, SC | Acute Care Hospitals | Voluntary non-profit - Other | 3 stars |
| NH Beaufort | Beaufort, SC | Acute Care - Department of Defense | Department of Defense | Not rated |
| Novant Health East Cooper Medical Center | Mount Pleasant, SC | Acute Care Hospitals | Proprietary | 4 stars |
| Novant Health Hilton Head Medical Center | Hilton Head Island, SC | Acute Care Hospitals | Voluntary non-profit - Other | 2 stars |
| Palmetto Lowcountry Behavioral Health | Charleston, SC | Psychiatric | Proprietary | Not rated |
| Patrick B Harris Psychiatric Hospital | Anderson, SC | Psychiatric | Government - State | Not rated |
| Pelham Medical Center | Greer, SC | Acute Care Hospitals | Government - Hospital District or Authority | 5 stars |
| Piedmont Medical Center | Rock Hill, SC | Acute Care Hospitals | Proprietary | 2 stars |
| Prisma Health Patewood Hospital | Greenville, SC | Acute Care Hospitals | Voluntary non-profit - Private | 5 stars |
| Prisma Health Baptist | Columbia, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Baptist Easley Hospital | Easley, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Baptist Parkridge | Columbia, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Greenville Memorial Hospital | Greenville, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Greer Memorial Hospital | Spartanburg, SC | Acute Care Hospitals | Voluntary non-profit - Private | 5 stars |
| Prisma Health Hillcrest Hospital | Simpsonville, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |
| Prisma Health Laurens County Hospital | Clinton, SC | Acute Care Hospitals | Voluntary non-profit - Private | 4 stars |